Prescription drugs that have an impact on liver metabolism can result in increased blood amounts of codeine. Do not give together with expectorants, For the reason that much more reproduced mucus can't be coughed off because of the antitussive impact of dihydrocodeine.

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artemether/lumefantrine will improve the degree or influence of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Check.

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methylene blue and codeine equally improve serotonin levels. Avoid or Use Alternate more info Drug. If drug combination needs to be administered, monitor for evidence of serotonergic or opioid-linked toxicities

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Lifetime-threatening respiratory melancholy and Demise have transpired in little ones who acquired codeine; codeine is topic to variability in metabolism based upon CYP2D6 genotype; based mostly on submit-advertising and marketing experiences, children < click here 12 a long time look like a lot more vulnerable to respiratory depressant outcomes of codeine, particularly if you will find threat elements for respiratory depression; situations of death are actually reported in the post-operative period pursuing tonsillectomy and/or adenoidectomy, and lots of read more of the kids had proof of being extremely-fast metabolizers of codeine

It's not a complete listing of feasible Uncomfortable side effects. For those who notice other outcomes not shown above, Get hold of your health care provider or pharmacist.